Thermo Fisher Scientific CUEDC1 Polyclonal Antibody
Rabbit polyclonal antibody against human CUEDC1 for WB and IHC applications. High antigen affinity purification ensures specificity. Provided in PBS with glycerol and sodium azide. Suitable for protein trafficking and degradation pathway research.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CUEDC1. Recombinant protein control fragment (Product # RP-93489) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2640248 |
Product Specific Information
Immunogen sequence:
DSIQGNAGGP KPGSGEGCPP AMAGPGPGDQ ESRWKQYLED ERIALFLQNE EFMKELQRNR DFLLALERDR LKYESQKSKS SSVAVGNDFG FSSP
Highest antigen sequence identity to orthologs:
- Mouse: 81%
- Rat: 82%
Target Information
The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ~40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation.
CUE domains are present in eukaryotic proteins involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found.
CUEDC1 (CUE domain-containing protein 1) is a 386 amino acid protein containing one CUE domain, suggesting a possible role in protein trafficking and degradation pathways. Two isoforms of CUEDC1 exist due to alternative splicing events.
Defects in the CUEDC1 gene may be associated with early-stage cervical cancer, implicating CUEDC1 as a potential tumor marker.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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