Thermo Fisher Scientific FOXO4 Monoclonal Antibody (OTI2C5), TrueMAB
인간 FOXO4 단백질(aa 206-505)에 특이적인 마우스 단클론 항체로 Western blot에 적합. TrueMAB 포맷으로 고순도 정제 및 안정적 액상 형태. PBS/BSA/glycerol 버퍼에 보존되며 -20°C에서 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 206–505 of human FOXO4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
FOXO4 (Forkhead box O4) is encoded by the FOXO4 gene located on the X chromosome. It is also known as AFX1 or MLLT7 (Myeloid/Lymphoid or Mixed-Lineage Leukemia Trithorax Homolog, Translocated To, 7) and belongs to the O class of forkhead/winged helix family of transcription factors along with FOXO1, FOXO3, and FOXO6.
FOXO4 is abundantly expressed in skeletal muscle and adipose tissue. It binds to the Insulin Responsive Element (IRE) and activates downstream targets of Insulin/IGF1 signaling such as IGFBP1.
Activation of the Insulin/IGF1 pathway via Akt leads to phosphorylation of FOXO4 on specific Ser/Thr residues, which mediates its binding to 14-3-3 and subsequent nuclear export.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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