Thermo Fisher Scientific P4HTM Polyclonal Antibody
Thermo Fisher Scientific의 P4HTM Polyclonal Antibody는 인간 PH-4 단백질을 표적으로 하는 토끼 유래 다클론 항체입니다. Western blot에 적합하며, 높은 종간 반응성을 보입니다. PBS 기반 용액 형태로 제공되며, 장기 보관 시 -20°C에서 보관 가능합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific P4HTM Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human PH-4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2884630 |
Product Specific Information
- Immunogen sequence: RLGNGWWMTP ESIQEMYAAI KADPDGDGVL SLQEFSNMDL RDFHKYMRSH
- Storage guidance:
- Short-term: 2–8°C, up to 1 week
- Long-term: -20°C, store in small aliquots to prevent freeze-thaw cycles
- Predicted homology:
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
Target Information
Prolyl hydroxylase 4 (P4HTM) is an enzyme that modifies HIF-alpha, a key transcriptional complex involved in oxygen homeostasis. Unlike collagen-modifying prolyl hydroxylases found in the endoplasmic reticulum, P4HTM acts intracellularly on HIF-alpha. Under normoxic conditions, it hydroxylates HIF-alpha, leading to its degradation via the von Hippel-Lindau ubiquitylation complex. Under hypoxic conditions, reduced hydroxylation stabilizes HIF, promoting angiogenesis. P4HTM thus functions as a cellular oxygen sensor and regulator of HIF stability.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.