Thermo Fisher Scientific CTCF Recombinant Rabbit Monoclonal Antibody (23GB3520)
CTCF 단백질을 인식하는 토끼 유래 재조합 단클론 항체. Western blot, ICC/IF, Flow cytometry 등 다양한 응용에 적합. 고순도 친화 크로마토그래피 정제, PBS/glycerol 완충액에 보관. 인간, 생쥐, 랫트에 반응.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB3520 |
| Immunogen | A synthetic peptide of human CTCF (680–727 AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain-containing, DNA-binding nuclear phosphoprotein involved in multiple aspects of gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation, and regulation of imprinted sites.
CTCF binds to the CCCTC DNA motif and interacts with HAT and HDAC complexes to modulate transcriptional activity. It participates in the transactivation of the APPB gene, silencing of the c-myc gene, insulation of human beta-globin and DMI myotonic dystrophy loci, and imprinting control of IGF2 and H19 regions.
Mutations in this gene have been associated with various cancers, including breast, prostate, and Wilms’ tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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