Thermo Fisher Scientific MRP4 Monoclonal Antibody (M4I-80)

Thermo Fisher Scientific MRP4 Monoclonal Antibody (M4I-80)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

The M4I-80 monoclonal antibody was selected after immunization with a fusion protein containing the E. coli maltose-binding protein and a fragment of the human MRP4 protein corresponding to amino acids 372–431.
MRP4 transports cyclic nucleotides and anti-retroviral compounds. The M4I-80 antibody also reacts with the mouse orthologue of the transporter molecule (Mrp4).

Target Information

The protein encoded by this gene belongs to the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes and are divided into seven distinct subfamilies.
This particular protein is a member of the MRP subfamily, which is involved in multi-drug resistance. Although the specific function has not been fully determined, it may play a role in cellular detoxification as a pump for organic anion substrates.
Alternative splicing results in multiple splice variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.