Thermo Fisher Scientific MOV10L1 Polyclonal Antibody
MOV10L1 단백질을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA에 적합하며, 항원 친화 크로마토그래피로 정제됨. 인간 시료 반응성, 고순도 액상 형태, 연구용 전용.
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- PA551004
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Thermo Fisher Scientific MOV10L1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:300 |
| ELISA | 1:5,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from the internal region of human MOV10L1 (amino acids 318–367, UniProt ID: Q9BXT6-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7.4) with 0.5% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2636452 |
Product Specific Information
MOV10L1 Polyclonal Antibody detects endogenous levels of MOV10L1 protein.
Target Information
Isoform 1:
ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, essential for germline integrity. Acts via the piRNA metabolic process by forming complexes with piRNAs and Piwi proteins, governing methylation and repression of transposons. Specifically binds piRNA precursors and promotes generation of intermediate fragments subsequently loaded onto Piwi proteins. Displays 5′–3′ RNA unwinding activity.
Isoform 2:
May act downstream of MEF2C during heart formation. Functions as a cardiac-specific suppressor of cardiomyocyte hypertrophy and cell cycle progression, possibly through regulation of CDKN1A.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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