Thermo Fisher Scientific NCOA4 Monoclonal Antibody (1A2)
NCOA4 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western Blot과 ELISA에 적합합니다. 인간 시료 반응성이 있으며, 액상 형태로 제공됩니다. 연구용으로만 사용 가능하며, 안정적인 -20°C 보관 조건을 권장합니다.
- 카탈로그번호
- H00008031-M02A
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Concentration: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A2 |
| Immunogen | NCOA4 (NP_005428, 505–614 a.a.) partial recombinant protein with GST tag (MW of GST tag = 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein:
EGSPKEVPGT EDRAGKQKFK SPMNTSWCSF NTADWVLPGK KMGNLSQLSS
GEDKWLLRKK AQEVLLNSPL QEEHNFPPDH YGLPAVCDLF ACMQLKVDKE KWLYRTPLQMTarget Information
Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor.
In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of chromosome in vivo.
ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion.
ARA70a is widely expressed, and its expression is highest in testis and adipose tissues, whereas ARA70b is solely expressed in the testis.
ARA70a can function as a ligand-enhanced co-activator of PPARγ in adipocytes.
ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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