Thermo Fisher Scientific NCOA4 Monoclonal Antibody (1A2)

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

ELISA

• Tested Concentration: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein:

EGSPKEVPGT EDRAGKQKFK SPMNTSWCSF NTADWVLPGK KMGNLSQLSS 
GEDKWLLRKK AQEVLLNSPL QEEHNFPPDH YGLPAVCDLF ACMQLKVDKE KWLYRTPLQM

Target Information

Androgen receptor (AR) coactivator ARA70, also designated NCOA4, RFG and ELE1, is a putative co-activator that specifically enhances the activity of the androgen receptor.
In human thyroid carcinomas, the Ret proto-oncogene fuses to ARA70 to form Ret/PTC3 by an intrachromosomal inversion of chromosome in vivo.
ARA70 is expressed as two isoforms, ARA70a and ARA70b. The shorter variant, ARA70b, results from an internal 985-bp deletion.
ARA70a is widely expressed, and its expression is highest in testis and adipose tissues, whereas ARA70b is solely expressed in the testis.
ARA70a can function as a ligand-enhanced co-activator of PPARγ in adipocytes.
ARA70 may be involved in prostate carcinogenesis and ovarian cancer and may serve as a key mediator of estrogen-androgen synergism.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.