Thermo Fisher Scientific CTNNA3 Polyclonal Antibody

Thermo Fisher Scientific CTNNA3 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, HepG2, HCT116
• Predicted reactivity: Human (99%), Mouse (92%), Bovine (94%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Catenins are proteins that connect cadherin/beta-catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alphaT-catenin is expressed in other tissues, with the highest levels observed in heart. Immunohistochemical analysis showed human alphaT-catenin localization at intercalated discs of cardiomyocytes and in peritubular myoid cells of testis. It has been proven that alphaT-catenin can functionally restore cell-cell adhesion in colon cancer cells lacking alpha-catenins, indicating involvement in specific muscle cell-cell contacts. The encoded protein has a predicted size of approximately 100 kDa and shares 57% amino acid identity with other alpha-catenins. In cells transfected with alphaT-catenin cDNA, interaction with alpha-catenin was demonstrated by coimmunoprecipitation. The 892_24D2S antibody against alphaT-catenin does not cross-react with alphaE-catenin or alphaN-catenin in western blot analysis.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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