Thermo Fisher Scientific NARF Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment, but it also plays roles in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This modified cysteine residue is removed from prelamin A during processing into mature lamin A.
The NARF protein binds to the prenylated prelamin A carboxyl-terminal tail domain and may be a component of a prelamin A endoprotease complex. It is located in the nucleus and partially colocalizes with the nuclear lamina. NARF shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified, including one generated by RNA editing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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