Thermo Fisher Scientific NARF Polyclonal Antibody
Thermo Fisher Scientific의 NARF Polyclonal Antibody는 인간, 생쥐, 랫트 시료에 반응하며 다양한 면역학적 분석(WB, IHC, ICC, ELISA)에 적합합니다. KLH 접합 합성 펩타이드로 면역화된 rabbit IgG 기반 항체로, 고순도 Protein A 정제 및 안정적인 액상 형태로 제공됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human NARF, amino acids 1–100 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment, but it also plays roles in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This modified cysteine residue is removed from prelamin A during processing into mature lamin A.
The NARF protein binds to the prenylated prelamin A carboxyl-terminal tail domain and may be a component of a prelamin A endoprotease complex. It is located in the nucleus and partially colocalizes with the nuclear lamina. NARF shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified, including one generated by RNA editing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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