Thermo Fisher Scientific CD54/ICAM-1 Monoclonal Antibody (ICAM1, 6319)
인간 ICAM-1(CD54)을 인식하는 Mouse Monoclonal Antibody로, IHC, ICC/IF, Flow Cytometry에 적합합니다. 단백질 A/G로 정제된 액상형 항체이며, PBS 버퍼에 0.05% BSA와 sodium azide가 포함되어 있습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- 3383-MSM5-P1
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ICAM1, 6319 |
| Immunogen | Recombinant full-length human ICAM1 protein (extracellular domain) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- For formalin-fixed tissues: Heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
ICAM-1 (CD54) is an 85–110 kDa single-chain type I integral membrane glycoprotein composed of five immunoglobulin superfamily repeats in its extracellular domain, a transmembrane region, and a cytoplasmic domain.
It has seven potential N-linked glycosylation sites and shares significant sequence homology with ICAM-2 (CD102) and ICAM-3 (CD50).
ICAM-1 binds to integrins such as CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1), and serves as a receptor for Rhinovirus.
It is expressed on activated endothelial cells, epithelial cells, fibroblasts, chondrocytes, and various immune cells including B and T lymphocytes, monocytes, macrophages, dendritic cells, and neutrophils.
Expression levels increase upon inflammation, and soluble ICAM-1 can be detected in plasma, often elevated in inflammatory conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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