Thermo Fisher Scientific CYP11A1 Polyclonal Antibody
CYP11A1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. Affinity chromatography로 정제된 1 mg/mL 액상 제품. PBS/glycerol 버퍼에 보관하며 -20°C에서 안정적 저장 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CYP11A1 (Accession P05108), corresponding to amino acid residues A411–Q461 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854464 |
Product Specific Information
This antibody detects endogenous levels of total Cytochrome P450 11A1.
Target Information
CYP11A1 (Cytochrome P450 11A1), also known as cytochrome P450C11A1, cytochrome P450scc, and cytochrome P450 subfamily XIA, is an enzyme that catalyzes the first step of steroid biosynthesis under cAMP signal modulation.
In steroidogenic cells, CYP11A1 converts cholesterol to pregnenolone, a process regulated by hormonal control of cholesterol availability. Expression of the CYP11A1 gene is controlled by the transcription factor SF-1, and the upstream SF-1 binding site is required for hormonal stimulation. c-Jun and SF-1 may act synergistically to activate CYP11A1 gene expression. Forskolin and 8-Br-cAMPS both elevate CYP11A1 mRNA levels in interstitial cell monolayers with functional adenylate cyclase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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