Thermo Fisher Scientific DTL Polyclonal Antibody
Western blot 및 Flow cytometry에 적합한 DTL 폴리클로날 항체. 인간 및 생쥐 반응성, Rabbit IgG 호스트 기반. KLH 결합 합성 펩타이드 면역원 사용. 고순도 Protein A 및 항원 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
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Thermo Fisher Scientific DTL Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 229–256 amino acids from the central region of human DTL |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2541953 |
Target Information
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response, and translesion DNA synthesis.
The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1).
CDT1 degradation in response to DNA damage ensures proper regulation of DNA replication.
CDKN1A/p21(CIP1) degradation during S phase or after UV irradiation controls replication licensing.
Substrates interact with PCNA via their PIP-box; those containing the K+4 motif recruit the DCX(DTL) complex, leading to degradation.
In proliferating cells, the DCX(DTL) complex also promotes Lys-164 monoubiquitination of PCNA, being involved in PCNA-dependent translesion DNA synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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