Thermo Fisher Scientific Cytokeratin 18 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human KRT18/Cytokeratin18.

Target Information

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins and exists in combination with cytokeratin 8.
It is expressed in tissues from the gastrointestinal, respiratory, and urogenital tracts, as well as endocrine, exocrine, and mesothelial cells. Cytokeratin 18 is primarily found in non-squamous epithelia and present in most adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18.
Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been identified.
Cytokeratin subtype expression patterns aid in distinguishing different epithelial malignancies. Cytokeratin antibodies are useful in the differential diagnosis of tumors (immunohistochemistry), cytopathology, and flow cytometry assays.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.