Thermo Fisher Scientific ZIP1 Polyclonal Antibody
ZIP1 단백질을 검출하기 위한 Rabbit Polyclonal Antibody로, WB, IHC, ICC 등 다양한 응용에 사용 가능. 인간, 마우스, 랫트 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관. 종양 억제 관련 ZIP1 연구에 적합.
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- PA5115913
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SLC39A1 (Accession Q9NY26), corresponding to amino acid residues L111–D161 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900547 |
Product Specific Information
Antibody detects endogenous levels of total SLC39A1.
Target Information
ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters.
Zinc is an essential ion for cells and plays significant roles in growth, development, and differentiation.
ZIP1 expression is markedly downregulated in various cancerous tissues and is considered a tumor suppressor gene in prostate cancer.
Overexpression of ZIP1 increases intracellular zinc levels in PC-3 cells, leading to inhibition of NF-kappa-B and downregulation of antiapoptotic proteins (Bcl-2, Bcl-XL, XIAP), thereby reducing the malignant potential of prostate cancer cells in vitro and in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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