Thermo Fisher Scientific p53AIP1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human p53AIP1. Recombinant protein control fragment (Product #RP-104123). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:p53AIP1,uniProtId:Q9HCN2-1,ncbiNodeId:9606,antigenRange:64-124,antigenLength:124,antigenImageFileName:PA5-61819_p53AIP1_Q9HCN2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-61819_p53AIP1_Q9HCN2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2645152

Product Specific Information

Immunogen sequence: GIEALSVSSG SWSSATVWIL TGLGLGLSRP FLPGATVLRD RPLGSAFELS YDQKKAPLRL Q

Highest antigen sequence identity to the following orthologs: Mouse - 28%, Rat - 30%.

Target Information

The novel protein p53AIP, p53-regulated apoptosis-inducing protein 1, has been identified from the direct cloning of p53 binding sequences from human genomic DNA. The expression of p53AIP1 in mitochondria is induced by wild-type p53, which leads to apoptotic cell death through dissipation of mitochondrial Dym. Severe DNA damage causes the phosphorylation of p53 at Ser-46, p53AIP1 expression, and apoptotic cell death. DNA damage-inducible apoptotic cell death was enhanced through transcriptional activation of p53AIP1. P53R2 is directly regulated by p53 for supplying nucleotides to repair damaged DNA, thus plays a pivotal role in cell survival by repairing damaged DNA in the nucleus and that dysfunction of this pathway might result in activation of p53 dependent apoptosis to eliminate dangerous cells. In the opposite, p53AIP1 is likely to play an important role in mediating p53-dependent apoptosis, and phosphorylation of Ser46 regulates the transcriptional activation of this apoptosis inducing gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.