Thermo Fisher Scientific HDAC4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,500

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4).
Histone deacetylation serves as an epigenetic repression marker and plays an important role in transcriptional regulation, cell cycle progression, and developmental processes.
HDAC4 acts through large multiprotein complexes and is involved in muscle maturation via interaction with myocyte enhancer factors (MEF2A, MEF2C, MEF2D).
It also participates in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Mutations in the HDAC4 gene have been linked to Brachydactyly-mental retardation syndrome (BDMR).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.