Thermo Fisher Scientific LRAT Polyclonal Antibody
LRAT 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·랫트 시료에 반응합니다. Western blot, IHC, ICC 등 다양한 응용에 적합하며, 고순도 친화성 크로마토그래피로 정제되었습니다. 비결합형 액상 형태로 -20°C에서 보관합니다.
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Thermo Fisher Scientific LRAT Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LRAT (Accession O95237), corresponding to amino acid residues Y118–C168 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818176 |
Product Specific Information
Antibody detects endogenous levels of total LRAT.
Target Information
Lecithin retinol acyltransferase (LRAT) is a membrane-bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A, generating all-trans-retinyl esters (tREs) in the liver and other tissues such as lung and retinal pigmented epithelium.
LRAT also exchanges palmitoyl groups between RPE65 and tREs, a process essential for vision. It plays a key role in dietary mobilization, transport, and storage of vitamin A and in the synthesis of the visual pigment chromophore.
LRAT monomers form homodimers through disulfide bond formation in membranes. Loss of LRAT correlates with early-onset severe retinal dystrophy and retinyl ester deprivation, while reduced LRAT expression may be linked to invasive bladder cancer.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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