Thermo Fisher Scientific MHC Class II (I-A/I-E) Monoclonal Antibody (CIa), Biotin

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1 µg/10^6 cells

-

Product Specifications

Species Reactivity

Avian, Chicken

Host/Isotype

Mouse / IgM, kappa

Class

Monoclonal

Type

Antibody

Clone

CIa

Immunogen

Splenic leukocytes from an outbred nine-week-old chicken

Conjugate

Biotin Biotin Biotin

View additional formats

• Unconjugated
• FITC
• PE
• Request custom conjugation

Form

Liquid

Concentration

0.5 mg/mL

Purification

purified

Storage buffer

PBS, pH 7.4, with proprietary stabilizer

Contains

<0.1% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2745766

Target Information

MHC (major histocompatibility complex) class II molecules are transmembrane glycoproteins expressed on the surface of professional antigen-presenting cells, such as macrophages, dendritic cells and B cells. Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15-24 amino acid residues long.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.