Thermo Fisher Scientific POLR3E Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, HeLa nucleus
• Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (82%), Xenopus laevis (80%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using ribonucleoside triphosphates as substrates.
POLR3E is a peripheral component of RNA polymerase III, synthesizing small RNAs such as 5S rRNA and tRNAs.
It is essential for efficient transcription from both type 2 VAI and type 3 U6 RNA polymerase III promoters.
POLR3E plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, acting as a nuclear and cytosolic DNA sensor in the innate immune response.
It can detect non-self dsDNA serving as a template for dsRNA transcription; these transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-κB through the RIG-I pathway.

주의사항

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.