Thermo Fisher Scientific POLR3E Polyclonal Antibody
Thermo Fisher Scientific의 POLR3E 폴리클로날 항체는 인간 POLR3E 단백질(aa 89–283)에 대응하는 재조합 항원으로 제작되었습니다. Western blot에 적합하며, HeLa 세포를 양성 대조군으로 권장합니다. RNA polymerase III 관련 연구에 유용하며, 비결합 상태로 액상 형태로 제공됩니다.
- 카탈로그번호
- PA531883
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment corresponding to amino acids 89–283 of Human POLR3E |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2549356 |
Product Specific Information
- Recommended positive controls: HeLa, HeLa nucleus
- Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (82%), Xenopus laevis (80%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using ribonucleoside triphosphates as substrates.
POLR3E is a peripheral component of RNA polymerase III, synthesizing small RNAs such as 5S rRNA and tRNAs.
It is essential for efficient transcription from both type 2 VAI and type 3 U6 RNA polymerase III promoters.
POLR3E plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, acting as a nuclear and cytosolic DNA sensor in the innate immune response.
It can detect non-self dsDNA serving as a template for dsRNA transcription; these transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-κB through the RIG-I pathway.
주의사항
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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