Thermo Fisher Scientific NEK4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human NEK4 protein kinase. Validated for IHC (Paraffin) with 1:20–1:50 dilution range. Antigen affinity purified, supplied as liquid in PBS with glycerol. Suitable for research use in signal transduction and cancer ...
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human NEK4. Recombinant protein control fragment (Product #RP-91410) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2644606 |
Product Specific Information
Immunogen sequence:
VAGECIIEKQ GRIHPDLQPH NSGSEPSLSR QRRQKRREQT EHRGEKRQVR RDLFAFQESP PRFLPSHPIV GKVDVTSTQK EAENQRRVVT GSVSSSRSSE MSSSKDRPLS ARERRRLKQS QEEMSSSGPS VRKASLSVAG PGKPQEEDQP
Highest antigen sequence identity to the following orthologs:
- Mouse: 60%
- Rat: 62%
Target Information
NEK4 is a serine/threonine kinase involved in signal transduction and cellular communication. It acts primarily on threonine residues and is expressed in most primary carcinomas. Protein kinases transfer phosphate groups from ATP to substrate proteins, mediating signal transduction and regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, apoptosis, and differentiation.
The protein kinase family includes over 500 gene products, classified into 8 major groups based on sequence comparisons of tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) contains 50 kinases related to MAPK cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, including MAPK and upstream kinases (MAPKKs), are well characterized in yeast pheromone response pathways, where pheromones activate MAPK signaling through Ste surface receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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