Thermo Fisher Scientific ZNRF2 Polyclonal Antibody

Thermo Fisher Scientific ZNRF2 Polyclonal Antibody

Applications and Tested Dilutions

• Western Blot (WB): 1:500–1:2,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:100–1:500

Product Specifications

Target Information

Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s), and the ubiquitin-protein ligases (E3s).
ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, endosome, and cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase involved in neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.