Thermo Fisher Scientific CCL5 (RANTES) Monoclonal Antibody (947A1H11), Biotin
인간 CCL5(RANTES)를 인식하는 단클론성 항체로, Biotin 결합형입니다. Sandwich ELISA 검출용으로 권장되며, >95% 순도(SDS-PAGE)로 정제되었습니다. Protein A로 정제된 액상형 제품으로 4°C 보관, 연구용으로만 사용됩니다.
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Applications
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 947A1H11 |
| Immunogen | Human recombinant RANTES |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS, pH 7.4, with 5 mg/mL BSA |
| Contains | 0.5 mg/mL sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536284 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
- Recommended as a detection antibody in Sandwich ELISA applications.
Target Information
CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes.
The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide.
CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils.
This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
Alternative splicing results in multiple transcript variants that encode different isoforms.
Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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