Thermo Fisher Scientific CCL5 (RANTES) Monoclonal Antibody (947A1H11), Biotin

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

• Purity is >95% by SDS-PAGE.
• Recommended as a detection antibody in Sandwich ELISA applications.

Target Information

CCL5 (RANTES) is a chemokine gene located on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes.
The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide.
CCL5, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells, and eosinophils. It causes the release of histamine from basophils and activates eosinophils.
This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.
Alternative splicing results in multiple transcript variants that encode different isoforms.
Diseases associated with CCL5 include Human Immunodeficiency Virus Type 1 and Periapical Granuloma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.