Thermo Fisher Scientific TNFRSF9 Monoclonal Antibody (OTI5H5), TrueMAB
TNFRSF9(4-1BB/CD137)을 인식하는 마우스 단클론 항체로, Western blot에 적합합니다. 인간 시료 반응성이 있으며, 액상 형태로 제공됩니다. 친화 크로마토그래피로 정제되었으며, PBS/BSA/glycerol 완충액에 보관됩니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5H5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 24–186 of human TNFRSF9 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD137 (also known as TNFRSF9 or 4-1BB) is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports survival and clonal expansion of activated and memory CD8+ T cells, while regulating myelopoiesis and dendritic cell development. Activation of CD137 induces cytokine release that modulates peripheral monocyte survival. Soluble CD137 may act as a negative regulator in immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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