Thermo Fisher Scientific CD223 Chimeric Recombinant Rabbit Monoclonal Antibody (C9B7W)
Thermo Fisher Scientific CD223 Chimeric Recombinant Rabbit Monoclonal Antibody (C9B7W)는 마우스 LAG-3 단백질의 D2 도메인에 특이적으로 결합하는 항체입니다. ICC/IF, Flow Cytometry, ELISA 등 다양한 응용에 사용 가능하며, HEK293 세포에서 발현된 재조합 단일클론 항체로 높은 특이성과 재현성을 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | 5,000 ng/mL |
| Immunoprecipitation (IP) | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | C9B7W |
| Immunogen | Lewis rats immunized with murine LAG-3:Ig fusion protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_3074655 |
Product Specific Information
This antibody is specific for an epitope in the D2 domain of murine LAG-3.
Target Information
LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4. It binds to MHC class II with higher affinity than CD4 and is involved in the negative regulation of T cell activation and homeostatic proliferation.
Surface expression of LAG-3 is observed on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells typically express LAG-3 at higher levels than CD4+ T cells.
Coexpression of LAG-3 and CD49b has been proposed as a marker for human and mouse Type 1 regulatory T cells (Tr1 cells).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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