Thermo Fisher Scientific UPF1 Polyclonal Antibody
UPF1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC/IF에 적합합니다. 인간, 마우스, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. NMD 관련 연구용으로 적합하며 4°C 단기, -20°C 장기 보관이 가능합니다.
- 카탈로그번호
- PA554031
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UPF1. Recombinant protein control fragment (Product #RP-91824). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649284 |
Product Specific Information
Immunogen sequence:
LEELWKENPS ATLEDLEKPG VDEEPQHVLL RYEDAYQYQN IFGPLVKLEA DYDKKLKESQ TQDNITVRWD LGLNKKRIAY FTLPKTD
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 99%
Target Information
Upf1 is an active component in nonsense-mediated decay (NMD), a eukaryotic mRNA surveillance mechanism that degrades mRNAs containing premature termination codons. It functions as an ATP-dependent RNA helicase localized in the cytoplasm and is also a component of cytoplasmic P-bodies. Phosphorylation of Upf1 mediates translation repression during NMD, facilitating mRNA accessibility to the NMD machinery. Other NMD components, Upf2 and Upf3, exhibit perinuclear and nucleocytoplasmic localization, respectively.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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