Thermo Fisher Scientific Calmodulin 3 Polyclonal Antibody
Calmodulin 3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, ICC/IF, ELISA에 적합하며 인간 및 마우스 반응성. 고순도 Affinity Chromatography 정제, 액상 형태로 안정적 보관 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1–149 of human CALM3 (NP_0017341) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 5.75 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804714 |
Product Specific Information
- Positive Samples: Mouse brain
- Cellular Location: Cytoplasm, cytoskeleton, spindle, spindle pole
Immunogen sequence:
MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK
Target Information
Calcium binding proteins (CaBP) play a crucial role in calcium-mediated cellular signal transduction in the central nervous system. The CaBP family shares similarity with CaM I (calmodulin) and can substitute or augment CaM I function.
CaBP7 contains two EF-hand domains for calcium binding and shares 70% homology with CaBP8 and 50% with CaM I. It negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity.
CaBP7 and CaBP8 possess a unique targeting mechanism that contributes to differential functional Ca²⁺-sensing among family members.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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