Thermo Fisher Scientific PPOX Polyclonal Antibody
Thermo Fisher Scientific의 PPOX Polyclonal Antibody는 인간 PPOX 단백질을 인식하는 토끼 유래 다클론 항체입니다. IHC(P) 및 ICC/IF에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 완충액에 보관되며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PPOX (Product # RP-94274) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645847 |
Product Specific Information
Immunogen sequence:
ETHLTSRGVS VLRGQPVCGL SLQAEGRWKV SLRDSSLEAD HVISAIPASV LSELLPAEAA PLARALSAIT AVSVAVVNLQ YQGAH
Highest antigen sequence identity to the following orthologs:
- Mouse: 81%
- Rat: 76%
Target Information
Protoporphyrinogen oxidase (PPOX) is the penultimate enzyme in the heme biosynthetic pathway, catalyzing the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. The PPOX protein localizes to the inner mitochondrial membrane in various tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Genetic deficiency of PPOX results in variegate porphyria, an autosomal dominant disorder characterized by cutaneous photosensitivity and/or neurological manifestations. The rare homozygous variant causes severe PPOX deficiency, leading to early-onset photosensitization, skeletal abnormalities of the hand, short stature, mental retardation, and convulsions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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