Thermo Fisher Scientific TCIRG1 Monoclonal Antibody (6H3)
TCIRG1 단백질을 인식하는 마우스 단클론 항체로, Western blot 및 ELISA에 적합합니다. 인간 시료에 반응하며, 비결합형 액상 형태로 제공됩니다. -20°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6H3 |
| Immunogen | TCIRG1 (AAH18133, 121 a.a. ~ 220 a.a.) partial recombinant protein with GST tag. MW of GST tag alone: 26 kDa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
QLHQLQLHAA VLRQGHEPQL AAAHTDGASE RTPLLQAPGG PHQDLRVNFV AGAVEPHKAP ALERLLWRAC RGFLIASFRE LEQPLEHPVT GEPATWMTFL
Target Information
The T-cell immune regulator 1 (TCIRG1) is the a3 subunit of the vacuolar-type proton transporting ATPase (V-ATPase), a proton pump located in late endosomes and lysosomes that functions in luminal acidification of these organelles.
Genetic defects in this gene cause a severe form of autosomal recessive osteopetrosis, characterized by increased bone density, reduced bone strength, and bone inflammation.
TCIRG1 is also essential for normal insulin secretion and macrophage-mediated bacterial killing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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