Thermo Fisher Scientific PSMB7 Monoclonal Antibody (OTI4G9)
PSMB7 단백질을 인식하는 Mouse monoclonal antibody (OTI4G9 클론). Western blot과 Immunocytochemistry에 사용 가능. Dog, Human, Mouse, Rat 등 다양한 종에 반응. 고순도 Affinity Chromatography 정제 및 안정적 PBS buffer 포뮬레이션.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4G9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 58–277 of PSMB7 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.59 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723530 |
Target Information
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure consists of four rings of 28 non-identical subunits: two rings of seven alpha subunits and two rings of seven beta subunits. Proteasomes are widely distributed in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
The immunoproteasome, a modified form of the proteasome, processes class I MHC peptides. The PSMB7 gene encodes a member of the proteasome B-type (T1B) family, which is a 20S core beta subunit. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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