Thermo Fisher Scientific SLA Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431
• Predicted reactivity: Mouse (87%), Rat (87%), Bovine (91%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

SLAP (Src-like-adapter protein 1) is a 276 amino acid adapter protein functioning as a negative regulator of T-cell receptor (TCR) signaling. It belongs to the SRC family of cytoplasmic tyrosine kinases and contains SH2 and SH3 domains. SLAP colocalizes with endosomes and inhibits T-cell antigen receptor-induced activation of nuclear factor of activated T-cells. It negatively regulates positive selection and mitosis of T-cells by linking signaling proteins such as ZAP70 with CBL, leading to CBL-dependent degradation of signaling proteins. Expression is weak in heart, adult brain, placenta, liver, skeletal muscle, kidney, and pancreas, but high in lung and fetal brain.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.