Thermo Fisher Scientific CD56 Monoclonal Antibody (MEM-188), TRI-COLOR

Applications

• Flow Cytometry (Flow): Assay-dependent
• View 5 publications

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• Alexa Fluor 647
• Biotin
• FITC
• PE
• PE-Cyanine5.5
• PE-Texas Red
• Request custom conjugation

Product Specific Information

The TRI-COLOR® conjugate is a tandem R-phycoerythrin (PE)-Cy5 conjugate that permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source—the 488 nm line of the argon-ion laser.

Target Information

CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120–180 kDa.
CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding, and synaptic plasticity. Polysialic modification reduces CD56-mediated cell adhesion.
Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins.
CD56 is expressed on most neuroectodermal-derived cell lines, tissues, and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas, and neuroblastoma.
Further, CD56 is a widely used neuroendocrine marker with high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.

Analyte Specific Reagent

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