Thermo Fisher Scientific GALE Monoclonal Antibody (OTI1C4)

Applications and Tested Dilution

Product Specifications

Target Information

This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.
The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids.
Mutations in this gene result in epimerase-deficiency galactosemia (galactosemia type 3), a disease characterized by liver damage, early-onset cataracts, deafness, and mental retardation, with symptoms ranging from mild (peripheral form) to severe (generalized form).
Multiple alternatively spliced transcripts encoding the same protein have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.