Thermo Fisher Scientific ESX1 Polyclonal Antibody

Thermo Fisher Scientific ESX1 Polyclonal Antibody

Applications

• Western Blot (WB)

Tested Dilution: 1.25 µg/mL
Publications: -

Product Specifications

Product Specific Information

• Peptide sequence:
  SLMARGGEDE ENTRSKPEYG TEAENNVGTE GSVPSDDQDR EGGGGHEPEQ
• Sequence homology: Human: 100%

Target Information

Homeobox proteins are transcription factors containing a helix-turn-helix DNA binding domain called the homeodomain.
ESX1 is an X-linked homeobox gene primarily expressed in the placenta and testis, with two functional domains: the homeodomain and the proline-rich domain.
During embryogenesis, ESX1 is expressed in extraembryonic tissues, including:

• Endoderm of the visceral yolk sac
• Ectoderm of the chorion
• Labyrinthine trophoblast of the chorioallantoic placenta

ESX1 can act as a transcriptional repressor of the human oncogene K-ras. Treatment of human cancer cells with an ESX1 protein fragment containing the homeodomain reduces the tumorigenicity of cells containing oncogenic K-ras mutations, suggesting ESX1 may be useful as a therapeutic target.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-41238_ESX1_Q8N693-1_Rabbit.svg, PA5-41238_ESX1_Q8N693-1_Rabbit_PDP.jpeg)