Thermo Fisher Scientific BMP10 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 22-316 of human BMP10 (NP_055297.1). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:BMP-10,uniProtId:O95393-1,ncbiNodeId:9606,antigenRange:22-316,antigenLength:424,antigenImageFileName:PA5-109449_BMP-10_O95393-1_Rabbit.svg,antigenImageFileNamePDP:PA5-109449_BMP-10_O95393-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.66 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2854860

Product Specific Information

Immunogen sequence: SPIMNLEQSP LEEDMSLFGD VFSEQDGVDF NTLLQSMKDE FLKTLNLSDI PTQDSAKVDP PEYMLELYNK FATDRTSMPS ANIIRSFKNE DLFSQPVSFN GLRKYPLLFN VSIPHHEEVI MAELRLYTLV QRDRMIYDGV DRKITIFEVL ESKGDNEGER NMLVLVSGEI YGTNSEWETF DVTDAIRRWQ KSGSSTHQLE VHIESKHDEA EDASSGRLEI DTSAQNKHNP LLIVFSDDQS SDKERKEELN EMISHEQLPE LDNLGLDSFS SGPGEEALLQ MRSNIIYDST ARIRR

Target Information

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-beta superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.