Thermo Fisher Scientific SGPL1 Polyclonal Antibody
Rabbit polyclonal antibody against human SGPL1 for WB, IHC, and ICC applications. Recombinant protein immunogen, unconjugated form, 0.5 mg/mL concentration. Suitable for research use only, stored at 4°C short term or -20°C long term.
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- PA582745
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SGPL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789901 |
Product Specific Information
Immunogen sequence:
SRDFDIYRLS NLMTAKGWNL NQLQFPPSIH FCITLLHARK RVAIQFLKDI RESVTQIMKN PKAKTTGMGA IYGMAQTTVD RNMVAELSSV FLDSLYSTDT VTQGSQMNGS PK
Target Information
Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. It elevates stress-induced ceramide production and apoptosis.
The catalytic activity of sphingosine-1-phosphate lyase converts sphingosine-1-phosphate to phosphoethanolamine and palmitaldehyde using pyridoxal phosphate as a co-factor.
Sphingosine-1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum and is primarily expressed in the liver and kidney. It belongs to the group II decarboxylase family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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