Thermo Fisher Scientific STAT4 Monoclonal Antibody (OTI2G5), TrueMAB
STAT4 단백질을 인식하는 Mouse monoclonal antibody (Clone OTI2G5). Western blot, ICC/IF, Flow cytometry에 사용 가능. Human STAT4에 반응하며, IL-12 신호전달 및 Th1 면역반응 연구에 적합. -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2G5 |
| Immunogen | Full length human recombinant protein of human STAT4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
STAT4 was originally identified using degenerate primers complementary to conserved regions of other STAT proteins. STAT4 shares similarity with STAT1 (52%) and STAT3 (47%) and can be tyrosine phosphorylated by Jak1 or Jak2. It forms homo- and heterodimers with related STAT family members and binds the IFN-gamma activated site (GAS). Serine phosphorylation is also required for maximal transcriptional activity.
STAT4 expression is mainly found in the thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which is essential for IFN-gamma production and Th1 immune response development. STAT4-deficient mice show impaired Th1 development and enhanced Th2 differentiation. In viral infection, IFN-α/β activation of STAT4 is required for IFN-γ production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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