Thermo Fisher Scientific JMJD1A Monoclonal Antibody (3G10C2)
JMJD1A 단백질을 인식하는 마우스 모노클로날 항체로, Western blot, ICC/IF, Flow cytometry, ELISA 등에 적합. 인간 시료 반응성이 높고, Protein G로 정제된 액상 형태. 연구용으로만 사용 가능하며 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G10C2 |
| Immunogen | Purified recombinant fragment of human KDM3A (AA: 311–445) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090779 |
Target Information
JMJD1A is a histone demethylase that specifically demethylates Lys-9 of histone H3, playing a central role in the histone code. It preferentially demethylates mono- and dimethylated H3 Lys-9 residues, especially the dimethylated form, while showing weak or no activity on trimethylated H3 Lys-9.
Demethylation of Lys residues generates formaldehyde and succinate. JMJD1A is involved in hormone-dependent transcriptional activation by participating in androgen receptor target gene recruitment, leading to H3 Lys-9 demethylation and transcriptional activation.
It also plays a role in spermatogenesis by regulating expression of genes such as PRM1 and TMP1, essential for sperm chromatin packaging and condensation. Additionally, JMJD1A contributes to obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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