Thermo Fisher Scientific UNC5B/UNC5H2 Polyclonal Antibody
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Applications
Tested Dilution
Publications
Western Blot (WB)
1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
1:400
Immunohistochemistry (Frozen) (IHC (F))
1:100-1:500
Immunocytochemistry (ICC/IF)
1:100-1:500
ELISA (ELISA)
1:500-1:1,000
Product Specifications
Species Reactivity
Human, Mouse, Rat
Host/Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human UNC5B, amino acids 188-260. if (typeof window.$mangular === undefined
|| !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{
targetFamily:
UNC5B,
uniProtId:
Q8IZJ1-1,
ncbiNodeId:
9606,
antigenRange:
188-260,
antigenLength:
945,
antigenImageFileName:
BS-11492R_UNC5B_Q8IZJ1-1_Rabbit.svg,
antigenImageFileNamePDP:
BS-11492R_UNC5B_Q8IZJ1-1_Rabbit_PDP.jpeg,
sortOrder:
1}\]
; $mangular.isB2BCMGT = false
; $mangular.isEpitopesModalImageMultiSizeEnabled = true
;
View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}
Conjugate
Unconjugated Unconjugated Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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