Thermo Fisher Scientific Thioredoxin 2 Polyclonal Antibody
Thioredoxin 2 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, Western blot에 적합합니다. 인간, 마우스, 랫트, 소에서 반응하며 고순도(>95%)로 정제되었습니다. 산화환원 관련 단백질 연구용으로 적합합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Thioredoxin 2 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-terminal region of human Trx2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2804023 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cysteine residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds.
Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx acts as a hydrogen donor for ribonucleotide reductase, an essential enzyme for DNA synthesis, and serves as a potent general protein disulfide reductase with numerous functions in growth and redox regulation.
Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and several transcription factors such as p53, NF-kB, and AP-1 (T1-151). Trx also contributes to H₂O₂ removal, particularly when coupled with methionine sulfoxide reductase or various peroxiredoxin isoforms.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.