Thermo Fisher Scientific TFEB Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

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Product Specifications

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human TFEB

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2662642

Product Specific Information

Immunogen sequence: LSGLGVFSSKM DAVPVILASP CQPLCFEEDT CLIYLLPLLI HREPAPAATM ASRIGLRMQL MREQAQQEEQ RERMQQQAVM HYMQ

Highest antigen sequence identity to the following orthologs - mouse 55%, rat 41%.

Target Information

The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors. Recent studies have shown that lysosomal biogenesis is regulated by TFEB, which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1. Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.