Thermo Fisher Scientific TFEB Polyclonal Antibody
Rabbit polyclonal antibody against human TFEB for ICC/IF applications. Recognizes recombinant human TFEB with high specificity. Useful for studying lysosomal biogenesis and autophagy regulation. Supplied as liquid, 0.1 mg/mL concentration, stored at 4°...
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Thermo Fisher Scientific TFEB Polyclonal Antibody
Applications
- Immunocytochemistry (ICC/IF)
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human TFEB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2662642 |
Product Specific Information
Immunogen sequence:
LSGLGVFSSKM DAVPVILASP CQPLCFEEDT CLIYLLPLLI HREPAPAATM ASRIGLRMQL MREQAQQEEQ RERMQQQAVM HYMQ
Highest antigen sequence identity to the following orthologs:
- Mouse: 55%
- Rat: 41%
Target Information
The Transcription factor EB (TFEB) is a member of the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors.
Recent studies have shown that lysosomal biogenesis is regulated by TFEB, which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1.
Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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