Thermo Fisher Scientific Phospho-c-Met (Tyr1313) Polyclonal Antibody
인간, 마우스, 랫트에서 인산화된 c-Met (Tyr1313)을 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot에 적합하며, 액상 형태로 1 mg/mL 농도. 암 관련 신호전달 연구 및 MET 인산화 상태 분석에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human Met (Phospho-Tyr1313) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2663103 |
Product Specific Information
Phospho-c-Met (Tyr1313) Polyclonal Antibody detects endogenous levels of c-Met only when phosphorylated at Tyr1313.
Target Information
MET (cMET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation of the ligand, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3. These interactions activate signaling cascades including RAS-ERK, PI3K-AKT, and PLCγ-PKC pathways.
MET plays a key role in embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation) and in adult processes such as wound healing, organ regeneration, and tissue remodeling.
Aberrant MET signaling has been associated with cancers including gastric, renal, and breast cancer, making it an important target for cancer therapeutics and diagnostic research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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