Thermo Fisher Scientific SH3BP4 Polyclonal Antibody
SH3BP4 단백질을 표적하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot에 적합하며 인간 샘플에 반응. 합성 펩타이드 면역원 사용, 고순도 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
- 카탈로그번호
- PA544269
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific SH3BP4 Polyclonal Antibody
Applications
- Western Blot (WB): 0.2–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human SH3BP4 (aa 71–120) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2576845 |
Product Specific Information
- Peptide sequence:
FTTLKFSKGD HLYVLDTSGG EWWYAHNTTE MGYIPSSYVQ PLNYRNSTLS - Sequence homology:
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
SH3BP4 was initially isolated as a novel cDNA using differential display analysis in cultured human corneal fibroblasts.
The protein contains three Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site.
SH3BP4 interacts with endocytic proteins such as clathrin, dynamin, and transferrin receptor (TfR), localizing to TfR-containing coated pits and vesicles.
It is involved in cargo-specific control of clathrin-mediated endocytosis, particularly in TfR internalization.
At least two isoforms of SH3BP4 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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