Thermo Fisher Scientific FADD Polyclonal Antibody
FADD 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin)에서 검증됨. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. 고순도(>95%) 제품으로 세포 사멸 신호 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 150–200 of Human FADD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803017 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
The FADD protein is an adaptor molecule that interacts with various cell surface receptors and mediates apoptotic signaling. Through its C-terminal death domain, it can be recruited by Fas receptor (TNFRSF6), TNFRSF25, and TRAIL receptor (TNFSF10), participating in death signaling initiated by these receptors. This interaction exposes the N-terminal effector domain, allowing recruitment of caspase-8 and activation of the cysteine protease cascade. Knockout studies in mice indicate its importance in early T-cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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