Thermo Fisher Scientific Carcinoembryonic Antigen (CEA)/CD66 Monoclonal Antibody (C66, 261)
CEA/CD66 단일클론 항체로 인간 시료에 반응하며, IHC, ICC/IF, Flow Cytometry에 적합합니다. 고순도의 Protein A/G 정제 항체로 4°C 보관하며, 연구용으로만 사용됩니다. 종양 표지자 연구 및 암 조직 식별에 유용합니다.
- 카탈로그번호
- 1048-MSM3-P0
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 0.5–1 µg/mL |
| Flow Cytometry (Flow) | 0.5–1 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C66, 261 |
| Immunogen | Recombinant full-length human CEA protein (CD66e, CEACAM5, UniProt ID: P06731-1, amino acids 1–702) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- For staining of formalin-fixed tissues: heat tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, then cool at room temperature for 20 minutes.
Target Information
Carcinoembryonic Antigen (CEA, CD66e) is synthesized during fetal gut development and re-expressed in intestinal carcinomas and other tumors.
CEA belongs to the immunoglobulin superfamily, containing one N domain and six constant-like domains (A1–A3, B1–B3).
Antibodies to CEA are useful for:
- Identifying the origin of metastatic adenocarcinomas
- Distinguishing pulmonary adenocarcinomas (60–70% CEA+) from pleural mesotheliomas (rarely or weakly CEA+)
CEA functions as a cell adhesion molecule found on leukocytes, epithelia, and endothelia, mediating homophilic and heterophilic interactions.
It is involved in processes such as tissue organization, angiogenesis, apoptosis, tumor suppression, metastasis, and immune modulation.
Multiple transcript variants encoding different isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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