Thermo Fisher Scientific Noelin Polyclonal Antibody, FITC
FITC로 표지된 Noelin-1 폴리클로날 항체로 신경계 발달 연구에 적합. Western blot, ELISA, IP 등 다양한 응용 가능. 토끼 유래 IgG 항체로 높은 특이성과 감도를 제공. -20°C 암소 보관, 연구용 전용.
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Thermo Fisher Scientific Noelin Polyclonal Antibody, FITC
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | C-epitope synthetic peptide within amino acid region 130–230 on Noelin-1 protein |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Olfactomedin family comprises a diverse group of secreted glycoproteins, including OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin, and myocilin. These proteins are implicated in nervous system development.
OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in cranial ganglia in mouse embryos (E8–10), and later in brain tissue and the zone of polarizing activity in the limb.
Overexpression of OLFM1 causes excess neural crest emigration and prolonged neural crest production. OLFM2 participates in the regulation of anterior nervous system development.
An Arg144Gln mutation in OLFM2 has been implicated as a possible cause of open-angle glaucoma (OAG).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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