Thermo Fisher Scientific Desmin (Muscle Cell Marker) Monoclonal Antibody (DES/1711)
Desmin 단백질을 표적하는 근육세포 마커 단일클론 항체로, Western blot, IHC, ICC, Flow cytometry 등 다양한 응용 가능. 인간, 마우스, 랫 등 여러 종에 반응하며, 높은 특이성과 안정성 제공. 연구용으로 적합.
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Thermo Fisher Scientific Desmin (Muscle Cell Marker) Monoclonal Antibody (DES/1711)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–4 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken, Hamster, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DES/1711 |
| Immunogen | Recombinant human desmin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Desmin (approximately 53 kDa) exhibits a high degree of tissue specificity, being predominantly expressed in muscle cells (cardiac, skeletal, and smooth muscle). Its expression is stage- and tissue-specific, induced during terminal development such as skeletal muscle differentiation.
In skeletal and cardiac muscle cells, desmin is localized in the Z-disk region and at the intercalated disk. Expression in smooth muscle is more heterogeneous.
Coexpression of vimentin and desmin has been observed in muscle-derived tumors such as rhabdomyosarcomas and leiomyosarcomas. During myocardial dysfunction, desmin distribution changes dramatically.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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배송/결제/교환/반품 안내
배송 정보
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