ELK Biotechnology p53 (phospho Ser15) rabbit pAb
인산화된 Ser15 부위를 인식하는 p53 폴리클로날 항체로, WB, IHC, IP, IF, ELISA에 적합합니다. 인간 및 랫트 시료에 반응하며, 세포 내 위치 연구 및 종양 억제 단백질 p53의 활성 분석에 유용합니다.
- 카탈로그번호
- ES1381-xxxxx (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology p53 (phospho Ser15) rabbit pAb
제품명
p53 (phospho Ser15) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53 |
| Applications | WB; IHC; IP; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IP: 2–5 µg/mg lysate IF: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human p53 around the phosphorylation site of Ser15 (AA range: 1–50) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 48 kDa |
| Gene ID (Human) | 7157 |
| Human Swiss-Prot No. | P04637 |
| Species Reactivity | Human; Rat |
세포 내 위치
Cytoplasm, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoskeleton (microtubule organizing center, centrosome).
Recruited into PML bodies with CHEK2 (PubMed:12810724).
Translocates to mitochondria upon oxidative stress (PubMed:22726440) or mitomycin C treatment (PubMed:27323408).
- Isoform 1: Predominantly nuclear, but also cytoplasmic when co-expressed with isoform 4
- Isoform 2: Mainly nuclear, minor cytoplasmic staining
- Isoform 3: Nuclear in most cells, cytoplasmic in some
- Isoform 4: Predominantly nuclear, translocates to cytoplasm
Background
Tumor protein p53 (TP53) encodes a tumor suppressor with transcriptional activation, DNA binding, and oligomerization domains. It responds to cellular stress by regulating target genes involved in cell cycle arrest, apoptosis, senescence, DNA repair, and metabolism.
Mutations in TP53 are linked to various human cancers, including hereditary forms such as Li-Fraumeni syndrome.
Alternative splicing and promoter usage generate multiple transcript variants and isoforms. Additional isoforms can arise from alternative translation initiation codons (PMIDs: 12032546, 20937277).
[Provided by RefSeq, Feb 2013]
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