ELK Biotechnology Met (phospho Tyr1234) rabbit pAb
Met 단백질의 인산화 Tyr1234 부위를 인식하는 rabbit polyclonal antibody로, WB, ELISA, IHC에 적합합니다. 인간, 마우스, 랫드, 원숭이에 반응하며, 고순도 IgG 형식으로 -20°C에서 1년간 안정적으로 보관 가능합니다.
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ELK Biotechnology Met (phospho Tyr1234) rabbit pAb
제품 개요
Met 단백질의 인산화 Tyr1234 부위를 인식하는 rabbit polyclonal antibody로, 다양한 생물종에서 Met 신호전달 연구에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Met (phospho Tyr1234) rabbit pAb |
| Alternative Names | MET; Hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met |
| Applications | WB; ELISA; IHC |
| Recommended Dilutions | WB 1:500–2000; IHC-p 1:50–300; ELISA 2000–20000 |
| Immunogen | Synthesized peptide derived from human Met around the phosphorylation site of Tyr1234 (AA range: 1201–1250) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 145 kD |
| GeneID (Human) | 4233 |
| Human Swiss-Prot No | P08581 |
| Cellular Localization | Membrane; Single-pass type I membrane protein; [Isoform 3]: Secreted |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in formation of the M10 peptide, which reduces lung fibrosis. Binding of hepatocyte growth factor induces dimerization and activation of the receptor, playing a role in cellular survival, embryogenesis, migration, and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression are also linked to multiple human cancers. (RefSeq, May 2016)
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