ELK Biotechnology Histone H2A.X (phospho Ser139) rabbit pAb
Histone H2A.X (phospho Ser139) rabbit polyclonal antibody는 인산화된 Ser139 위치를 인식하며, WB, IHC, IF, ELISA에 사용 가능. 인간, 마우스, 랫, 햄스터 반응성. 고순도 IgG로 핵 내 히스톤 구조 연구에 적합.
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Histone H2A.X (phospho Ser139) rabbit pAb
제품 개요
Histone H2A.X (phospho Ser139) rabbit polyclonal antibody는 인간 Histone H2A.X 단백질의 Ser139 인산화 부위를 인식하도록 설계되었습니다. 핵 내 히스톤 구조 및 DNA 손상 반응 연구에 활용됩니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product Name | Histone H2A.X (phospho Ser139) rabbit pAb |
| Alternative Names | H2AFX; H2AX; Histone H2A.x; H2a/x |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Histone H2A.X around phosphorylation site of Ser139 (AA range: 94–143) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 15–19 kDa |
| GeneID (Human) | 3014 |
| Human Swiss-Prot No | P16104 |
| Cellular Localization | Nucleus; Chromosome |
| Species Reactivity | Human; Mouse; Rat; Hamster |
Background
Histones are basic nuclear proteins responsible for the nucleosome structure of chromosomal fiber in eukaryotes. Two molecules each of H2A, H2B, H3, and H4 form an octamer, around which approximately 146 bp of DNA is wrapped to form nucleosomes. The linker histone H1 interacts with linker DNA between nucleosomes and contributes to chromatin compaction.
This gene encodes a replication-independent histone belonging to the H2A family, generating two transcripts through conserved stem-loop termination and polyA addition motifs.
[provided by RefSeq, Oct 2015]
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