ELK Biotechnology HDAC4 (phospho Ser632) rabbit pAb
HDAC4의 Ser632 인산화 부위를 인식하는 토끼 폴리클로날 항체. WB 및 ELISA에 적합하며, 핵과 세포질 간 이동 연구에 활용 가능. 고순도 IgG, 1 mg/ml 농도, -20°C 보관 안정성 우수.
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제품명
HDAC4 (phospho Ser632) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | HDAC4; KIAA0288; Histone deacetylase 4; HD4 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HDAC4 around the phosphorylation site of Ser632. AA range: 598-647 |
| Host Species | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 119 kD |
| Gene ID (Human) | 9759 |
| Human Swiss-Prot No. | P56524 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Nucleus, Cytoplasm. Shuttles between the nucleus and cytoplasm. Upon muscle cell differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on interaction with a 14-3-3 chaperone protein and phosphorylation at Ser-246, Ser-467, and Ser-632 by CaMK4 and SIK1. Nuclear localization likely depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity).
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
[provided by RefSeq, Jul 2008]
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